Effect of regression to the mean on decision making in health care

Knowledge of regression to the mean can help with everything from interpreting test results to improving your career prospects. All healthcare professionals should be aware of its implication

Evidence for risk of bias in cluster randomised trials: review of recent trials published in three general medical journals

Objective To examine the prevalence of a risk of bias associated with the design and conduct of cluster randomised controlled trials among a sample of recently published studies. Design Retrospective review of cluster randomised trials published in the BMJ, Lancet, and New England Journal of Medicine from January 1997 to October 2002. Main outcome measures Prevalence of secure randomisation of clusters, identification of participants before randomisation (to avoid foreknowledge of allocation), differential recruitment between treatment arms, differential application of inclusion and exclusion criteria, and differential attrition. Results Of the 36 trials identified, 24 were published in the BMJ, I I in the Lancet, and a single trial in the New England journal of Medicine. At the cluster level, 15 (42%) trials provided evidence for secure allocation and 25 (69%) used stratified allocation. Few trials showed evidence of imbalance at the cluster level. However, some evidence of susceptibility to risk of bias at the individual level existed in 14 (39%) studies. Conclusions Some recently published cluster randomised trials may not have taken adequate precautions to guard against threats to the internal validity of their design

Developing Interventions for Children's Exercise (DICE): a pilot evaluation of school-based exercise interventions for primary school children aged 7 to 8 years.

BACKGROUND: Developing Interventions for Children's Exercise (DICE) is an initiative aimed at determining effective school-based exercise programs. To assess feasibility, we conducted a pilot study of exercise sessions which varied in duration and frequency. METHODS: Exercise interventions were delivered to Year 3 pupils (age 7-8 years; n = 73) in primary schools within Yorkshire, UK. Evaluations were conducted using focus group sessions, questionnaires and observations. RESULTS: The study revealed positive aspects of all interventions, including favorable effects on children's concentration during lessons and identified the value of incorporation of the DICE concept into curriculum lessons. Children appeared enthused and reported well-being and enjoyment. Areas requiring attention were the need for appropriate timetabling of sessions and ensuring the availability of space. CONCLUSION: The concept and sessions were well-accepted by teachers who confirmed their full support of any future implementation There appears to be potential for the encouragement and empowerment of teachers to support physical activity and healthy school environments, and to take an interest in the health of their pupils. Ultimately, these findings should assist in the design of successful exercise interventions in the school setting

Investigation of a single-photon source based on quantum interference

We report on an experimental investigation of a single-photon source based on a quantum interference effect first demonstrated by Koashi, Matsuoka, and Hirano [Phys. Rev. A 53, 3621 (1996)]. For certain types of measurement-based quantum information processing applications this technique may be useful as a high rate, but random, source of single photons.Comment: Submitted to the New J. Phys. Focus Issue on "Measurement-based quantum information processing

Limit on the Temporal Variation of the Fine-Structure Constant Using Atomic Dysprosium

Over a period of eight months, we have monitored transition frequencies between nearly degenerate, opposite-parity levels in two isotopes of atomic dysprosium (Dy). These transition frequencies are highly sensitive to temporal variation of the fine-structure constant ($\alpha$) due to relativistic corrections of large and opposite sign for the opposite-parity levels. In this unique system, in contrast to atomic-clock comparisons, the difference of the electronic energies of the opposite-parity levels can be monitored directly utilizing a radio-frequency (rf) electric-dipole transition between them. Our measurements show that the frequency variation of the 3.1-MHz transition in $^{163}$Dy and the 235-MHz transition in $^{162}$Dy are 9.0$\pm$6.7 Hz/yr and -0.6$\pm$6.5 Hz/yr, respectively. These results provide a value for the rate of fractional variation of $\alpha$ of $(-2.7\pm2.6)\times 10^{-15}$ yr$^{-1}$ (1 $\sigma$) without any assumptions on the constancy of other fundamental constants, indicating absence of significant variation at the present level of sensitivity.Comment: 4 pages, 2 figure